In addition, disrupted/mutated forms of several of these genes (SNCA, FOS, ARHGAP26, HDC, CLN8, SELENBP1, FTH1, ADIPOR1, FBXO7, PIP4K2A, SRXN1, DOPEY2, GMPR, RNF213, DCAF16, DCAF12) have been implicated in various neuropsychiatric and neurodegenerative diseases (Table 2; detailed in Table S3). Here, HDC is linked to neurodegenerative disease.