In addition, disrupted/mutated forms of several of these genes (SNCA, FOS, ARHGAP26, HDC, CLN8, SELENBP1, FTH1, ADIPOR1, FBXO7, PIP4K2A, SRXN1, DOPEY2, GMPR, RNF213, DCAF16, DCAF12) have been implicated in various neuropsychiatric and neurodegenerative diseases (Table 2; detailed in Table S3). The gene discussed is GMPR; the disease is neurodegenerative disease.