In addition, disrupted/mutated forms of several of these genes (SNCA, FOS, ARHGAP26, HDC, CLN8, SELENBP1, FTH1, ADIPOR1, FBXO7, PIP4K2A, SRXN1, DOPEY2, GMPR, RNF213, DCAF16, DCAF12) have been implicated in various neuropsychiatric and neurodegenerative diseases (Table 2; detailed in Table S3). This evidence concerns the gene PIP4K2A and neurodegenerative disease.