A more extensive comparison of DNA methylation (Figure 3B) with additional cell lines and tissues revealed that EWS-iPS cells possessed methylation patterns that more closely resembled those of lower passaged ES and iPS cell lines and were distinct from the methylation patterns of the more differentiated tissues (differentiated ES and iPS cells, hydatidiform moles, the TC32 EWS cell line and the CHLA-10 Ewing parent cell lines). Here, EWSR1 is linked to hydatidiform mole.