POU5F1 and cancer: This appeared to be the case in a recent study which attempted to reprogram a EWS cell line via employing a herpesvirus saimiri-based (HSV) 3 factor (OCT4, NANOG, and LIN28) vector; these cells, termed “induced multipotent cancer cells (iPCs),” yielded only a partially reprogrammed phenotype capable of differentiation toward the ectodermal lineage (Brown et al., 2013).