Specifically, Zheng et al. showed that p53 inactivation enhanced the production of inflammatory cytokines IL-1, −6, and −12 by macrophages [76] while we demonstrated that the genetic deletion of p53 enhanced IL-6-induced Th17 differentiation and promoted the spontaneous development of autoimmunity in p53nullCD45.1 mice [26]. Here, TP53 is linked to Autoimmunity.