However, the association showed a different pattern in samples stratified by histology: RARβ2 expression showed a reciprocal relationship with EGFR expression in adenocarcinoma and with c-MET expression in squamous cell carcinoma, suggesting that RARβ2 may interact with EGFR or c-MET in a tissue-dependent manner. This evidence concerns the gene EGFR and adenocarcinoma.