However, RARβ2 hypermethylation was not associated with the composite scores of β-catenin (P = 0.65; Wilcoxon rank-sum test), c-MET (P = 0.30), cyclin D1 (P = 0.38), E-cadherin (P = 0.21), or EGFR (P = 0.07), suggesting that there may be no interaction between RARβ2 and the five proteins in never-smokers with adenocarcinoma. Here, EGFR is linked to adenocarcinoma.