NR1H4 and rheumatoid arthritis: Interestingly, the top canonical pathways were as follows: (1) FXR/RXR activation, (2) granulocyte adhesion and diapedesis, (3) altered T-cell and B-cell signaling in rheumatoid arthritis, (4) hepatic cholestasis, and (5) agranulocyte adhesion and diapedesis.