IRS1 and type 2 diabetes mellitus: Of these seven loci, we found evidence for age-associated differential methylation at SSR1/RREB1 and LPP. We also looked for any age-associated epigenetic evidence for genes established through approaches other than GWAS and found that the following known T2D genes are under epigenetic regulation by age: IRS1 [60], IRS2 [54], AKT [61], ABCC8 [62], HNF4A [63], IPF-1(PDX1) [64], NeuroD1 [65], and GCK [66].