TP53 and plasma cell myeloma: RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule that blocks p53/MDM2 interaction (Issaeva et al., 2004); however, it appeared to be rather unspecific since its pro-apoptotic capacity was described to be p53-independent in several tumors, including myelomas (Surget et al., 2014) and additional data indicated that RITA cannot inhibit this interaction in vitro (Krajewski et al., 2005).