Notwithstanding, it is interesting to note that cGMP and its associated signaling pathways have received considerable attention recently for the treatment of cardiovascular disorders including hypertrophy, hypertension, ischemia, and reperfusion injury (Garcia-Dorado et al., 2009; van Heerebeek et al., 2012; Greene et al., 2013; Lukowski et al., 2014), and the possible link between GPR35 and cGMP may therefore deserve further attention. Here, GPR35 is linked to cardiovascular disorder.