CCL5 is required for the US28-mediated activation of RhoA (Melnychuk et al., 2004), focal adhesion kinase (FAK), and ERK (Vomaske et al., 2009) via Gα12/13 proteins in smooth muscle cells, mouse fibroblasts and U373 glioblastoma cells infected with adenoviruses expressing US28, whereas CX3CL1 activates FAK and ERK via Gαq in fibroblasts. The gene discussed is PTK2; the disease is glioblastoma.