Later genetic manipulations in mice appeared to confirm SIRT1’s beneficial effect in Huntington’s disease (HD; Jeong et al., 2011; Jiang et al., 2011), but the SIRT1 inhibitor selisistat was recently shown to alleviate HD pathology in Drosophila and mouse models (Smith et al., 2014). This evidence concerns the gene SIRT1 and Huntington disease.