Later genetic manipulations in mice appeared to confirm SIRT1’s beneficial effect in Huntington’s disease (HD; Jeong et al., 2011; Jiang et al., 2011), but the SIRT1 inhibitor selisistat was recently shown to alleviate HD pathology in Drosophila and mouse models (Smith et al., 2014). The gene discussed is SIRT1; the disease is juvenile Huntington disease.