SIRT1 could also modulate BDNF expression via the deacetylation of methyl-CpG binding protein 2 (MeCP2; Zocchi and Sassone-Corsi, 2012), a transcription factor mutated in the neurodevelopmental disorder Rett Syndrome (Guy et al., 2011; Liyanage and Rastegar, 2014). This evidence concerns the gene MECP2 and neurodevelopmental disorder.