However, contrasting the above, the SIRT1 inhibitor nicotinamide was also shown to attenuate/delay cognitive effects of 3xTg-AD mice (triple transgenic for mutant Psen1, App(swe) and Tau) via SIRT1 inhibition and reduction of Tau phosphorylation (Green et al., 2008). The gene discussed is MAPT; the disease is Alzheimer disease.