N-nitroso-N-ethylurea (ENU) mutagenesis was utilized to generate missense mutations of Disc1. L100P mutant (Disc1L100P/L100P) mice showed reduced brain volume, reduced number of cortical neurons, altered distribution of cortical neurons, interneuonal migration deficits, and schizophrenia-like behavioral abnormalities, although the behavioral phenotypes were not confirmed by another group due to the difference in the genetic background (Clapcote et al., 2007; Lee et al., 2011, 2013; Shoji et al., 2012). Here, DISC1 is linked to schizophrenia.