The behavioral abnormalities and neurodevelopmental disorders of Dgcr8+/− mice are similar but some of them are milder than those of 22q11DS model mice,(Stark et al., 2008; Meechan et al., 2009; Fenelon et al., 2011), which might suggest that additional haplodeletion of other genes in 22q11-related regions might be required for the complete reconstitution of phenotypes of 22q11DS model mice. The gene discussed is DGCR8; the disease is 22q11.2 deletion syndrome.