Neuron-specific overexpression of the truncated DISC1 also resulted in drastic phenotypes: enlarged lateral ventricle, reduced number of PV-positive interneurons and schizophrenia-like behavioral abnormalities (Hikida et al., 2007; Pletnikov et al., 2008; Shen et al., 2008; Ayhan et al., 2011) (Table 2). This evidence concerns the gene DISC1 and schizophrenia.