PRNP and prion disease: In prion disease, the pathological conformation is the primary infectious agent (Soto and Satani, 2011; Munch and Bertolotti, 2012) that propagates using a mechanism called “seeding/nucleation” where PrPSc acts like a seed that recruits and converts soluble protein into aggregates of PrPC which form polymers (Moreno-Gonzalez and Soto, 2011; Munch and Bertolotti, 2012).