The key features of the disease are: 1) congenital hypochromic, microcytic anemia; 2) very low MCV (patients present with marked microcytosis and hypochromia that are disproportionate to the degree of anemia); 3) low transferrin saturation; 4) abnormal iron absorption; 5) defective iron utilization (as evidenced by sluggish and incomplete response to parenteral iron); and 6) an inheritance mode compatible with autosomal recessive transmission [1]. This evidence concerns the gene TF and anemia (phenotype).