Interestingly, Nie et al. recently reported a 10-year-old Chinese female with a triallelic polymorphism of TMPRSS6 (homozygous for c.757 A>G and heterozygous for c.2207 T>C [rs855791]), who presented with severe hypochromic, microcytic anemia (Hb 58 g/L) at the age of 15 months [62]. Here, TMPRSS6 is linked to microcytic anemia.