Mice with a knockout of the PDGFR-β gene (PDGFR-β KO) display cognitive deficits (e.g., deficits in prepulse inhibition [PPI], fear conditioning, and spatial memory) and behavioral changes related to negative symptoms (impeded social interaction, depressive-like immobility) of schizophrenia and autism as well as reduction of phase-locked gamma-band activity and parvalbumin-immunoreactive neurons [15]. This evidence concerns the gene PVALB and Cognitive impairment.