MRPS7 and metabolic acidosis: Translational deficiencies due to mutations in genes encoding MRPs have been described for four of the more than 70 MRPs, leading to growth retardation, cardiomyopathy, hypotonia, and brain anomalies [88–91] but are expected to range from lethality to slightly impaired energy metabolic deficiencies and give rise to various tissue-specific defects such as neuromuscular disorders or metabolic acidosis [92, 93].