We used formalin-fixed paraffin-embedded (FFPE) tumors to investigate protein expression levels of ALK using immunohistochemistry (IHC), to evaluate the frequency of ALK gene amplifications and copy number changes with fluorescence in situ hybridization (FISH), and to elucidate the prevalence, clinicopathological characteristics, and prognostic relevance of ALK gene alterations in IBC. The gene discussed is ALK; the disease is inflammatory breast carcinoma.