NEU3 and colitis: NEU3 transgenic mice have also provided evidence of the involvement of this sialidase in carcinogenesis, in terms of an increase in azoxymethane- induced aberrant crypt foci [13], whereas Neu3- knock out mice exhibited reduction of tumor incidence in a colitis-associated colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate [14].