By integrating copy number, methylation, gene expression and protein-protein interaction data of ovarian cancer, we built an integrated co-alteration network (ICan) based on CCA, and identified 155 cancer-related genes, including TP53, BRCA1, RB1 and PTEN; and novel cancer-related genes, such as PDPN and EphA2. Here, RB1 is linked to cancer.