Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper (bHLH-Zip) factor, regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells (Goding, 2000; Widlund and Fisher, 2003; Steingrimsson et al., 2004). This evidence concerns the gene MITF and melanoma.