TFAP2A is a TF involved in melanoma (Huang et al., 1998) and normal melanocyte function (Brewer et al., 2004; Van Otterloo et al., 2010) and co-localizes with MITF at promoters involved in pigment cell differentiation in primary human melanocytes (H Seberg, E van Otterloo, and RA Cornell, manuscript in preparation). The gene discussed is TF; the disease is melanoma.