ANXA8 and acute promyelocytic leukemia: A similar association of ANXA8 with committed human progenitor cells and cancer had previously been found in the haematopoietic system, where AnxA8 mRNA expression was detected in pro-myelocytes and was further up-regulated in APL [69], a leukaemia in which the c-kit+ve progenitor cell population is abnormal and expanded.