Since c-kit+ve/ERα−ve luminal progenitor cells have recently been shown to be the origin of basal-like breast cancers [42,68], and since ANXA8 is strongly associated with this subgroup, it is possible that ANXA8 expression in these cancers is a reflection of ANXA8’s close association with luminal progenitor cells, and that the pro-quiescence function of ANXA8 might be perturbed. This evidence concerns the gene ANXA8 and breast cancer.