Gene expression studies in MDS cases showed altered expressions of oncogenes (N-RAS, WT1) and genes involved in cell cycle regulation (CDKN2B, EVI-1), apoptosis (BCL2, C-MYC, TP53), DNA methylation (DNMT3A, TET2, IDH1/IDH2), and histone deacetylation (H3K27, EZH2, UTX, ASXL1) [3–6]. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.