Compared to RCMD, RAEB exhibited a down-regulation of target genes of transcription factor Zic family member 1 (ZIC1), stimulated by retinoic acid 13 (STRA13), upstream stimulatory factor (USF), and aryl hydrocarbon receptor-hypoxia inducible factor (AhR-HIF). The gene discussed is AHR; the disease is myelodysplastic syndrome with multilineage dysplasia.