PTEN and intrahepatic cholangiocarcinoma: Furthermore, for the first time, we describe the effects of miR-21 on its potential target genes protein tyrosine phosphatase non-receptor type 14 (PTPN14), and PTEN in various malignant phenotypes of ICC cells in vitro and in vivo. Finally, we detected the expression of miR-21, PTPN14 and PTEN in tissues of ICC patients, and characterized the clinicopathological correlation of miR-21, PTPN14, and PTEN in ICC.