To explore the role of PTEN and PTPN14 in ICC cells, we constructed plasmid vectors expressing PTPN14 and PTEN without the 3′-UTR, and confirmed their efficacy on levels of PTPN14 and PTEN proteins in REB cells (Supplementary Figure 2). The gene discussed is PTPN14; the disease is intrahepatic cholangiocarcinoma.