Because the ATRX antibody from Bethyl Laboratories is unable to be used for IHC we could not examine this; however, we were able to look at MDM2 levels in seven paired pre- and post-treatment biopsies from individual WD/DDLS patients enrolled in our phase II clinical trial with PD0332991 (NCT01209598) [24]. The gene discussed is MDM2; the disease is Wilson disease.