MYH1 and Other metabolic disease: Second, a tendency towards increased gene expression of MYH1 (encoding the protein myosin heavy chain 2X, present in fast-glycolytic type 2 fibers) and MYH2 (encoding the protein myosin heavy chain 2A, present in fast-oxidative type 2 fibers) in individuals with prediabetes or type 2 diabetes suggests a higher proportion of more fast muscle fibers (fast-glycolytic and fast-oxidative) in patients with metabolic disease.