Qualitative analysis of relative stroma area assessed by a pathologist (H.E.R.)indicated augmented pancreatic fibrosis in the STP mice in comparison to the MT-TGFα mice, which was confirmed by the quantitative analysis of the relative pancreatic area positive for vimentin expressions by IHC (Fig. 5B; MT-TGFα: 56.7%±4.4; STP: 75.0%±5.8; Student’s t-test, p = 0.003) and also by Western blot analysis of vimentin expressions in the total protein extracts from pancreata of the S4, MT-TGFα and STP mice (Fig. 5C). This evidence concerns the gene VIM and fibrosis.