In addition, polymorphisms in protein tyrosine phosphatase N22 (PTPN22), peptidyl arginine deiminase type IV (PADI4), signal transducer and activator of transcription 4 (STAT4), and TNF receptor-associated factor 1/complement C5 (TRAF1/C5) were found associated with RA [8]. This evidence concerns the gene STAT4 and rheumatoid arthritis.