CRHR1 and depressive symptom measurement: In the association studies of variants in CRHR1 with depression [35] and responses to antidepressants [36], three SNPs, namely, rs1876828, rs242939, and rs242941, were investigated, which revealed that the rs242941 G/G genotype and haplotype G-A-G of the three SNPs are associated with fluoxetine therapeutic response in major depressive disorder (MDD) patients with high anxiety.