TNF and Familial prostate cancer: Our preclinical studies show that ATC armed with Her2Bi exhibited high levels of non-MHC restricted cytotoxicity directed at PC-3, DU-145, and LNCaP prostate cancer cell lines and produced tumoricidal cytokines such as interferon γ (IFNγ), tumor necrosis factor α (TNFα), and GM-CSF as well as MIP1alpha and RANTES [10–22].