Excessive nutrient intake is key in the genesis of obesity and type 2 diabetes: adipocytes and macrophages in the white adipose tissue respond to molecules such as free fatty acids, advanced glycation end products and reactive oxygen species (Figure 4) with the production of TNF-α, IL-1β, IL-6, CCL2 and adipokines like leptin [80]. The gene discussed is LEP; the disease is Obesity.