While this intersects with recent reports that NLRP3 also contributes to amyloidosis and cognitive dysfunction in the APP/PS1 model of AD [104], it is important to recognise that the former study shows an influence of low grade chronic sterile systemic inflammation on brain aging and cognition in a manner that is IL-1-dependent, in the absence of amyloid pathology. This evidence concerns the gene APP and amyloidosis.