Since IL-1β is known to contribute to osteoarthritis pathology, the Col1-IL1βXAT Cre inducible model was used to model osteoarthritis and when these animals were crossed with APP/PS1 mice and injected with Cre to induce chronically elevated IL-1β expression, there were significant exacerbations of Aβ deposition and associated microglial activation [64]. The gene discussed is APP; the disease is osteoarthritis.