Importantly, this more rapid cognitive decline can be dissociated from amyloid levels: in a longitudinal study of aging (Vantaa 85+) episodes of delirium increased the risk of dementia by eight-fold, but while dementia in the overall population was strongly associated with Aβ plaques, Tau tangles, infarcts and α-synuclein Lewy bodies, those associations were lost in patients that became demented after delirium [11]. The gene discussed is MAPT; the disease is dementia.