Interestingly, the overexpression of FLT3 at B-ALL diagnosis and at one and two months after starting treatment was associated with relapse/death in our study group; these findings were established without regard to subclassification by clinical characteristics and were significant in children (time 2), adults (time 3), and standard risk (time 2) subgroups. Here, FLT3 is linked to acute lymphoblastic leukemia.