Common cytogenetic subtypes abnormalities such as TEL-AML1 (ETV6-RUNX1)/t(12;21), BCR-ABL (BCR-ABL1)/t(9;22), MLL rearrangements/t(11q23), E2A-PBX1 (TCF3-PBX1)/t(1;19), MYC-IGH/[t(8;14), t(2;8) or t(8;22)], and hyperdiploidy/(50 chromosomes) are typically associated with ALL prognosis and together with age, white blood cell (WBC) count, leukemic cell immunophenotype, and time to respond to therapy define the risk stratification group [7]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.