In a study of 115 patients with acute dyspnea with and without acutely decompensated heart failure, higher levels of galectin-3 were significantly but weakly correlated with Doppler indices of higher filling pressure (E/e′, r = 0.345) and more extensive diastolic relaxation abnormalities (e′, r = −0.246) [56]. This evidence concerns the gene LGALS3 and heart failure.