The most promising agents are cardiotrophin-1 [40–44], soluble endoglin [45], pancreatitis-associated protein [46], ST2 [47–49], growth differentiation factor 15 [50, 51], galectin-3 [52–57], and carbohydrate antigen-125 [58], even if one cannot exclude other agents, in which data on their relation to LVFP and HFpEF are still insufficient or missing. The gene discussed is GDF15; the disease is pancreatitis.