Immunogenic profiles have been widely described as important factor associated with susceptibility and evolution of HIV-1 infection, especially those single nucleotide polymorphisms (SNPs) in cytokines genes that regulate the imune response like TNFα, IFNγ, TGFβ, IL-10, and IL-6, but few reports have focused patients from the Amazon region of Brazil, where the people have a genetic background composed by the mix of three ethnic groups. The gene discussed is IFNG; the disease is HIV-1 infection.