Therefore, the present study aimed to evaluate the occurrence of a possible association of TNFα-308G/A, IFNγ+874T/A, TGFβ-509C/T, IL-10-1082A/G, and IL-6-174G/C polymorphisms with HIV-1 infection in Brazilians residing in the northern part of country and its influence on laboratory markers of AIDS progression (CD4+ T lymphocytes and plasma viral load). This evidence concerns the gene CD4 and HIV-1 infection.