PCLAF and breast neoplasm: 2012). PAF-AH inhibition led to the enhanced PAF accumulation and increased polymorphonuclear leukocyte (PMN) adherence in human microvascular lung endothelial cells (HMVEC-L) (Sharma et al. 2012). We have also recently demonstrated cigarette smoke exposure increases adherence of MDA-MB-231 breast tumor cells to the lung endothelium (Kispert et al. 2014). This inhibition could be abrogated by pretreatment of MDA-MB-231 cells with an iPLA2β inhibitor, (S)-bromoenol lactone (S)-BEL, which inhibits PAF production (Kispert et al. 2014).