The receptors for most of the prostaglandins showed only limited regulation; however, the PGE2 receptor Ptger3 was found to be downregulated in ob/ob mice on both an mRNA and protein level (Figure 1d and Supplementary Figures S6A and B), whereas the PGF2α receptor Ptgfr was found to be downregulated by both dietary conditions and genetic obesity on an mRNA level (Figure 1d) and by short-term HFD and in the ob/ob model on a protein level (Supplementary Figures S6A and B). The gene discussed is PTGFR; the disease is Genetic obesity.