CD4 and cancer: IL-12 increases the synthesis of interferon (IFN)-γ by NK and T cells, stimulates the growth and cytotoxicity of activated NK, CD8+ and CD4+ T cells, induces differentiation of CD4+ Th0 cells into Th1 phenotype, enhances antibody-dependent cell cytotoxicity against cancer cells, and induces IgG antibodies and inhibits the synthesis of IgE antibodies by B lymphocytes (Lasek et al. 2014).