Interestingly, based on apoptosis, HPIP overexpression reduced sensitivity of HCT-116 cells to Oxaplatin, a chemotherapy drug used for treatment of CRC, whereas HPIP knockdown increased sensitivity of HCT-8 cells to Oxaplatin, because the altered amplitude of HPIP-regulated apoptosis with Oxaplatin was different from that without Oxaplatin (Fig. 4A, 4B). Here, PBXIP1 is linked to colorectal carcinoma.