MAPK3 and colorectal carcinoma: Fig. 4). Treatment with LY294002 or PD98059 blocked the phosphorylation of AKT and ERK1/2, respectively (Fig. 6C & Supplementary. Fig. 4C & Supplementary Fig. 8A–E). Importantly, treatment with LY294002 or PD98059 greatly alleviated the ability of HPIP to regulate CRC cell proliferation and migration as well as the expression of the cell cycle regulators and the EMT markers (Fig. 6C & Supplementary. Fig. 4C & Supplementary Fig. 8F–K).