Consistent with the results of HPIP modulation of CRC cell migration and invasion, overexpression of HPIP promoted epithelial-mesenchymal transition (EMT), which has been shown to play a critical role in cancer cell migration and invasion7, with morphologic changes from a polarized epithelial phenotype to an elongated fibroblastoid phenotype, whereas HPIP knockdown repressed EMT (Fig. 5E, 5F). This evidence concerns the gene PBXIP1 and cancer.