CCND1 and colorectal carcinoma: Our study shows that inhibition of ERK1/2 and AKT by PD98059 and LY294002 in HPIP-overexpressing CRC cells attenuates the ability of HPIP to promote CRC cell proliferation and migration and to regulate the expression of the important cell cycle regulators cyclin D1, cyclin A and cyclin B1 as well as the EMT regulators E-cadherin and N-cadherin, suggesting that activation of ERK1/2 and AKT is critical for HPIP modulation of the proliferation and migration of CRC cells and of the expression of cell cycle and EMT regulators.