Closely associated pathways involving similar proteins (‘inhibition of matrix metalloproteases’, ‘intrinsic prothrombin activation pathway’, ‘atherosclerosis signalling’, ‘heme degradation’, ‘basal cell carcinoma signalling’, ‘Il-8 signalling’, ‘role of Wnt/GSK-3β signalling’ and ‘germ cell-sertoli cell junction signalling’) were also deregulated in XRCC1 KD cells (Tables 1 and 3, ‘tissue remodelling’). The gene discussed is CXCL8; the disease is atherosclerosis.