以“gefitinib”、“erlotinib”、“icotinib”、“afatinib”、“non small lung cancer”、“chemotherapy”、“EGFR mutation”、“never smokers”、“adenocarcinoma”、“clinical selected”为关键词,在Pubmed、Embase、American Society of Clinical Oncology(ASCO)、European Society for Medical Oncology(ESCO)及生物医学数据库中检索近10年来EGFR-TKI与化疗相比一线治疗NSCLC疗效的相关文献。. This evidence concerns the gene EGFR and adenocarcinoma.