HTRA1 and age-related macular degeneration: Moreover, the SERPING1 SNPs have no statistical interaction with SNPs in the two major AMD genes, CFH and HTRA1. Furthermore, the meta-analysis revealed that the common SNPs rs2511989, rs1005510, rs2511990 and rs11603020 in SERPING1 were not significantly associated with all forms of AMD or neovascular AMD in Japanese and Chinese, and the SNP rs2511989 was not associated with PCV.