IL1B and chronic granulomatous disease: Initial studies implicated the NADPH oxidase (NOX) complex7, 8, but more recent work found that macrophages derived from knockout mice for the NOX1, NOX2 or NOX4 component of this complex did not impair IL1β secretion, and macrophages derived from patients with chronic granulomatous disease due to mutations of this complex were still capable of secreting IL1β in response to DAMPs1, 3, 9.