We previously screened epilepsy-dependent molecules using a temporal lobe epilepsy (TLE) [11, 12] mouse model in which kindling stimulation is applied repeatedly to the amygdala [13] and found that sialyltransferase ST3Gal IV is upregulated in neurons located within the neural circuits that kindling stimulation propagates [14]. Here, ST3GAL4 is linked to epilepsy.