In a previous study, we have shown that transduction of human ras homolog enriched in brain (hRheb) with a mutation of serine to histidine at position 16 [hRheb(S16H)] exerted neurotrophic effects in dopaminergic neurons via the activation of mammalian target of rapamycin complex 1 (mTORC1), resulting in the protection and restoration of the nigrostriatal dopaminergic projection in a neurotoxin model of PD [12, 13]. This evidence concerns the gene RHEB and Parkinson disease.