Similar to CNTF neutralization, this treatment significantly attenuated hRheb(S16H)-induced neuroprotection in both dopaminergic neurons and fibers in the MPP+-treated model of PD [Figs. 4B and C; p = 0.016 and p < 0.001 for TH-positive neurons and fibers, respectively, vs. hRheb(S16H) + MPP+]. This evidence concerns the gene CNTF and Parkinson disease.