Our previous studies have shown that a constitutively active form of Rheb, such as hRheb(S16H), could induce neurotrophic effects in SNpc dopaminergic neurons, stimulate the production of dopamine in the nigrostriatal dopaminergic system, and induce neuroprotective and restorative effects via the activation of the mTORC1 signaling pathway in animal models of PD [12, 13]. Here, RHEB is linked to Parkinson disease.