HIF1A and familial pancreatic carcinoma: Moreover, the SCF/c-kit binding has been reported to increase hypoxia-inducible factor-1α (HIF-1α) protein synthesis by the PI3K and Ras/MEK/ERK pathways in pancreatic cancer cells under normoxia, and hypoxia up-regulated SCF gene expression in breast cancer cells through HIF-1α [5].