EDNRA and pulmonary arterial hypertension: Although the pathophysiological role of EDNRA and EDNRB has not yet been completely elucidated, EDNRA is considered a bad receptor involved in pathogenesis and the development of various diseases as systemic and pulmonary hypertension, atherosclerosis, diabetes, and cardiac remodeling after myocardial ischemia [13, 15, 16].