Cushing’s syndrome (CS) due to chronic exposure to endogenous hypercortisolism may be caused by a pituitary adenoma, an adrenocortical tumor or ectopic adrenocorticotropic hormone (ACTH) or corticotropin-releasing hormone (CRH) production [1]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.