Although previous studies have shown an effect of heterozygous and homozygous knockout of CX3CR1 on amyloid plaque burden in Alzheimer-transgenic mice ([16]; [17]), in our hands plaque density, plaque area, plaque size and microglia area were indistinguishable in cortex and hippocampus of APP-PS1(dE9) and APP-PS1(dE9)xCX3CR1+/- (S1 Fig). Here, CX3CR1 is linked to amyloidosis.