Further, microarray analysis revealed the downregulation of Ces3 expression in the liver of Rm155LG/Alb-Cre mice (Fig. 7B), while qRT-PCR analysis demonstrated that Ces3 mRNA levels in the liver of Rm155LG/Alb-Cre mice were significantly down-regulated (Fig. 7C), and ectopic expression of miR-155 in BEL-7402 (Fig. 7D) and BEL-7404 (Fig. 7E) human hepatocellular carcinoma cell lines resulted in significant reduction of endogenous Ces3. Here, CES3 is linked to hepatocellular carcinoma.