Lissencephaly, a developmental cortical disorder, is associated with defects in ‘core’ genes such as ARX, stage-specific genes such as DCX, and Notch active specific genes such as VLDLR. Similarly, Microcephaly is associated with defects in ‘core’ genes such as MCPH1 and STIL, stage-specific genes such as CENP, and Notch active specific genes such as ASPM. Our data sets may provide insights also to other nervous system disorders such as autism as well as psychiatric disorders. The gene discussed is VLDLR; the disease is lissencephaly spectrum disorders.