Limited activity was reported of sorafenib in recurrent glioblastoma and in the first-line therapy for glioblastoma.[12–14] Recently, sorafenib, crizotinib and dasatinib have been introduced in pediatric brain tumors.[15,16] Overall, the preliminary results of single receptor tyrosine kinase targeted tumor therapies are disappointing. The gene discussed is NTRK1; the disease is brain neoplasm.