Furthermore decrease of apoptotic cells after HGF addition to canertinib 2 uM in Res-259 cells and after EGF addition to sorafenib 1 uM in Res-196 cells, could also be exceeded by crizotinib or canertinib respectively (61,5% and 36.9% more apoptotic tumor cells). The gene discussed is HGF; the disease is neoplasm.