The CSF IL-10 high levels and significantly lower rate ratios of IFN-γ/IL-10 and IL-2/IL-10 observed among CM patients suggest Th1 dysregulation is pivotal and may contribute to CM pathogenesis in AIDS patients similar to that described in transplanted patients ​and those with idiopathic CD4 lymphopenia [42,51]. This evidence concerns the gene IL10 and AIDS.